Denovo (30 capsules)

Denovo (30 capsules)

SKU: 58407-1500-30

Denovo is a dietary supplement used for the metabolic management of low folate levels, which may sometimes be associated with mood disorders. Folate, which is one of the body’s essential B vitamins, helps the brain naturally improve your mood.


Click here to view full Denovo product brochure. 


An estimated 70% of people in the United States have low levels of active folate, which can result in our bodies not producing enough of the neurotransmitters serotonin, dopamine and norepinephrine – which have a direct correlation to our mood and feelings. Each Denovo capsule contains 15 mg of L-methylfolate calcium salt, which is an active form of folate. This means that once taken, your body can quickly and easily absorb the folate. Even if you lack the MTHFR enzyme, your body will still be able to absorb the folate in Denovo. Denovo is specially formulated to treat the root cause of your symptoms, not just mask them. For 79 cents or less per day, you can declare victory with Denovo! 


Why Denovo? Because Denovo contains an active folate that your body can absorb easily and quickly, Denovo is priced significantly lower than similar brands, Denovo does not require a prescription, and Denovo contains adequate amounts of folate for you to feel results.


Denovo can help symptoms of: sadness, anxiety, discouragement, hopelessness, short-temperedness, seasonal "blues", gloominess, despair, irritability, stress, tearfulness, hypersensitivity and many more. 


Gluten-free, Sugar-free, Dairy-free & Soy-free

Denovo does NOT contain any undesirable fungal additives.



Click here to read an article from the American Journal of Psychiatry titled 'L-Methylfoate as Adjunctive Therapy for SSRI-Resistant Major Depression: Results of Two Randomized, Double-Blind, Parallel-Sequential Trials'.

Price Options
One-time purchase
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$23.95monthly/ auto-renew

    Active Ingredients:  15mg L-methylfolate (L-5-MTHF from L-5-methyltetrahydrofolate calcium salt)

    Inactive Ingredients: microcrystalline cellulose, gelatin, vegetable magnesium stearate, silica, titanium dioxide, FD&C yellow #5, FD&C yellow #6

    Uses: Denovo® is indicated for the distinct metabolic requirements of individuals who have suboptimal L-methylfolate levels in the cerebrospinal fluid, plasma, and/or red blood cells and have major depressive disorder (MDD) with particular emphasis as adjunctive support for individuals who are on an antidepressant.

    Warnings: Folic acid, when administered in daily doses above 0.1mg, may obscure the detection of B12 deficiency (specifically, the administration of folic acid may reverse the hematological manifestations of B12 deficiency, including pernicious anemia, while not addressing the neurological manifestations.) 5-MTHF may be less likely than folic acid to mask B12 deficiency. Folate therapy alone is inadequate for the treatment of B12 deficiency.

    Caution is recommended in patients with a history of bipolar illness. Patients with depressive symptoms should be adequately screened to determine if they are at risk for bipolar disorder. 


    Take one capsule daily, or as recommended by your healthcare professional.

    Each bottle contains 30 tablets.


    "After giving birth, I struggled with post-partum depression. I had been on prescription antidepressants in the past and really did not want to go on one again due to the associated side effects. Denovo was reccomended to me as an alternative. It is truly a fantastic product! It worked just as well, if not better, than the antidepressants I have been on in the past. Denovo helped me feel like myself again! I continue to take it daily because not only does it reduce my irritability and depressed feelings, I feel like it gives me more energy - which I need!"

    - Whitney from Louisville, KY 


    "I have been using Denovo since May of 2019 because I suffer from depression. I was taking four prescriptions to battle my symptoms. Since I began taking Denovo, I have been able to cut down to one prescription. The combination of the prescription antidepressant and Denovo has resulted in my moods leveling off. I do not feel like I am always up or down anymore. I feel amazing! I have not been able to say that in a long time. My husband has also begun taking Denovo and says that he has more energy."

    - Lori from Lilburn, GA


    Note: The statements in all testimonials are the opinions of the contributor and have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.